Osteoarthritis (OA) is a major cause of chronic pain. With modern medicine improving, the prevention, diagnosis and treatment of many diseases is now making people living longer. This increased life expectancy has led to an increased in degenerative wear and tear over use conditions including osteoarthritis.

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In the normal joint, healthy cartilage allows bones to glide easily over each other. It also helps absorb the shock of movement by its cushion-like effect. Osteoarthritis is the most common joint disease that mostly affects cartilage particularly of major joints (such as the knee) due to chronic stresses on the joints from, for example, certain jobs and playing sports, obesity, genetic defects in joint cartilage or due to injury. It is common in the elderly due to wear and tear on the joint and rubbing of joint surfaces; this leads to the destruction of cartilage and eventually narrowing of joint space, swelling, loss of joint movement, stiffness and significant pain. Pain is the most common symptom of osteoarthritis. It usually occurs when the joint is moved and improves at rest. It gradually becomes more severe due to the progression of disease and the development of inflammation (swelling). The pain and stiffness affect the function of the joints and impacts upon a person’s everyday life. Treatment focuses on pain relief and improving the physical function of the joint. In the most severe cases, surgical replacement of the osteoarthritic joint can be performed, but this is major surgery and carries surgical risks and complications. The aim of this study is to look at whether an injection of fat from another area of the body into a knee with severe osteoarthritis improves their condition.

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